Dallas Braden of the Oakland Athletics throws the 19th perfect game in Major League Baseball history in a 4-0 win over the Tampa Bay Rays.
The Houston Astros defeat the Philadelphia Phillies in Game 6 of the 2022 World Series, winning the series 4 games to 2. They clinched their second World Series title, their first since 2017. At 73, Dusty Baker became the oldest in Major League Baseball history to win the World Series as a manager, while Jeremy Peña became only the third rookie to win MVP.
Chiba Lotte Marines pitcher Rōki Sasaki is taken out after throwing 102 pitches and eight perfect innings to end his attempt for a second consecutive perfect game, one week after completing his first one.
Chiba Lotte Marines pitcher Rōki Sasaki throws a perfect game, the first in 28 years and the 16th in NPB history, tying the existing NPB record by striking out 19 batters, and setting a new record by striking out 13 consecutive batters.
Major League Baseball reaches a labor collective bargaining agreement with the Major League Baseball Players Association to end the lockout and salvage a 162-game season. Opening day will begin on April 7 and training camp will begin tomorrow.
In Major League Baseball, the Atlanta Braves defeat the Houston Astros to win the World Series. This marks the Braves' first World Series title since 1995.
Major League Baseball announces that it will move this year's All-Star Game from Atlanta in response to the U.S. state of Georgia passing a series of controversial voting laws that critics say disproportionately target the state's minority voters.
An 11-judge panel of the U.S. Ninth Circuit Court of Appeals overturns the 2011 conviction of all-time Major League Baseball home run leader Barry Bonds on obstruction of justice charges stemming from the BALCO doping scandal.
Former American Major League Baseball player Roger Clemens is acquitted on all charges in a perjury trial.
Alex Rodriguez of the New York Yankees becomes the seventh player in the history of Major League Baseball to hit 600 home runs.
Roy Halladay pitches the 20th perfect game in Major League Baseball history in the Philadelphia Phillies' 1–0 win over the Florida Marlins.