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Sinovac Biotech's CoronaVac appears to be safe in providing protection against COVID-19, as preliminary results of Phase III clinical trial in Brazil show. São Paulo's Instituto Butantan, one of Brazil's leading biomedical research centres carrying out the trials, says CoronaVac proved to be safe after its two doses were applied to 9,000 volunteers, but said data on how effective it is in protecting people against COVID-19 will not be released until it has been tested on all 15,000 volunteers in newly expanded trials.

Taoiseach Micheál Martin announces that Ireland will move to Level Five for a period of six weeks. The new restrictions will take effect at midnight on October 21 and remain in place until December 1. Under Level Five restrictions, non-essential business will close, people will only be able to exercise within 5 km of their homes except for essential reasons, and no social or family gatherings are allowed in homes or gardens. However, schools and creches are to remain open, and elite sporting events can take place.

First Minister Mark Drakeford announces that Wales will introduce a "firebreak" lockdown, which will require anyone to stay home between October 23 and November 9. Under those rules, pubs, restaurants, hotels, and non-essential businesses must close; primary schools will reopen after the half-term break, but only seventh and eighth years in secondary schools can return at that time under the new "firebreak" rules. In addition, gathering with people from other households indoors or outdoors will be banned.