2021–22 EuroLeague In basketball, Anadolu Efes defeat Real Madrid 58–57 in the championship game at Štark Arena in Belgrade, Serbia, to win their second EuroLeague title.
2021–22 UEFA Women's Champions League In association football, Olympique Lyonnais defeat Barcelona 3–1 in the final at Juventus Stadium in Turin, Italy, to win their eighth UEFA Women's Champions League title.
United States An early heat wave in the United States sets all-time high records for May 21 in several cities in Texas, Mississippi, Virginia, Maryland and Delaware, and ties them for some other areas, particularly in the Northeast.
Heat wave An unusually early heat wave in Southern France continues to set all-time high records for May, with some communities reporting temperatures as high as 36.7 C.
2022 Australian federal election ABC News Australia declares that Australian Prime Minister Scott Morrison and the current government have been defeated by Anthony Albanese and the Australian Labor Party. However, the number of seats to declare a majority or minority government is uncertain.
COVID-19 pandemic The Philippines reports its first case of the Omicron BA.4 variant in a person who recently travelled to the Middle East.
Mealhada Three people are killed and more than 30 are injured in a bus crash on the motorway near Mealhada, Portugal.
Copper mine Two workers are killed in an accident at the Khoemacau copper mine in Botswana. Authorities temporarily shut down the mine.
2022 Russia–European Union gas dispute Russia's Gazprom suspends natural gas exports to Finland over Finland's refusal to comply with Russia's demand that gas be paid for in rubles.
Israeli–Palestinian conflict A 17-year-old member of the Palestinian Islamic Jihad is killed and another is injured during clashes with Israeli soldiers in Kafr Dan, Jenin Governorate.
Maghreb insurgency An elderly Italian couple and their son are kidnapped by jihadists in Southern Mali. A Togolese citizen is also reported to have been kidnapped along with the Italians, but authorities say that they are unable to confirm if this is true.
Russo-Ukrainian War United States President Joe Biden signs into law a bill that would provide $40 billion in military and economic aid for Ukraine, replenish stocks of U.S. equipment sent to Ukraine, fund European Command operations, and address the global food crisis.